Abstract
Biomaterials based on seeding of cells on decellularized scaffolds have gained increasing interest in the last few years and suggested to serve as an alternative approach to bioengineer artificial organs and tissues for transplantation. The reaction of the host toward the decellularized scaffold and transplanted cells depends on the biocompatibility of the construct. Before proceeding to the clinical application step of decellularized scaffolds, it is greatly important to apply a number of biocompatibility tests in vitro and in vivo. This review describes the different methodology involved in cytotoxicity, pathogenicity, immunogenicity and biodegradability testing for evaluating the biocompatibility of various decellularized matrices obtained from human or animals.
Research Abstract
Research Department
Research Journal
Materials Science and Engineering: C
Research Member
Research Publisher
ELSEVIER
Research Rank
1
Research Vol
67
Research Website
https://www.ncbi.nlm.nih.gov/pubmed/27287176
Research Year
2016
Research Pages
766-778