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Zinc Oxide Nanoparticles Prevents Multidrug Resistant
Staphylococcus-Induced Footpad Dermatitis in Broilers

Research Authors
Usama T. Mahmoud
, Madeha H.A. Darwish
, Fatma Abo Zakaib Ali
,Omar A. Amen
, Manal A.M. Mahmoud
, Omar B. Ahmed
, Ghada Abd El-Reda
, Mohamed A. Osman
, Aly A. Othman
, Mostafa F.N.Abushahba
, Ramadan D. El Shoukary
Research Abstract

The current experiment was designed to evaluate the effects of
dietary supplementations of zinc oxide nanoparticles (ZONPs) on
some behavioural, performance, welfare and histopathological
changes in broilers exposed to multidrug resistant Staphylococcus
aureus (MRSA)-induced footpad dermatitis(FPD). Eighty-four
males Indian River (IR) broilers were randomly allotted to six
different dietary treatments as follows C-ve, C+ve, 10, 20, 30 and
40 ppm ZONPs from 7- 49ds of age. At day 28, broilers (n = 70)
were subcutaneously injected 0.5mL of saline containing 5.3 ×
107
cfu/ mL of S. aureus (MRSA) in each metatarsal foot pad.
Control (non-infected) broilers were given 0.5 mL of saline (n =
14). Results clarified that non-infected birds and ZONPs fed birds
had significantly higher standing and feeding activities and lower
resting activities in comparison with the infected group. Also, the
S. aureus infected group had significantly lower body weight gain
(BWG) and higher feed conversion ratio (FCR) than the noninfected group. In addition, the non-infected birds and ZONPs
groups had significantly lower object crossing and tonic
immobility times (TI) and gait scores (GS) in comparison with the
S. aureus group. Only ZONPs 30, 40 ppm and non-infected groups
had significantly higher latency to lie time (LLT) and lower serum
cortisol level in comparison with the S. aureus group. Moreover,
4
there were significant changes in the gross lesion score and
histopathological lesion between the different groups. In
conclusion, the dietary supplementation of ZONPs can reduce S.
aureus induced negative effects of FPD in broilers

Research Department
Research Journal
Avian Pathology
Research Publisher
Taylor & Francis & Houghton Trust Ltd
Research Rank
1
Research Vol
NULL
Research Website
10.1080/03079457.2021.1875123
Research Year
2021
Research Pages
NULL