Aims: We evaluate the effect of enzyme replacement therapy "ERT" on the plasma levels of some
biochemical markers of the disease burden, in pediatric patients with Gaucher's disease "GD", in the
form of plasma chitotriosidase "ChT", total acid phosphatase activity, ferritin and globulin to evaluate
the therapeutic monitoring efficacy of such biomarkers.
Methodology: A cross sectional case control study, carried out on 26 GD pediatric patients, divided
into group A (13): On ERT and group B (13): Not receiving ERT, and in addition to 20 healthy age and sex matched controls. ELISA assays of plasma ChT and ferritin, colorimetric assays of plasma
total acid phosphatase activity and globulin, were done for all groups, while, plasma proteins
electrophoresis was done for GD patients only.
Results: Significant higher plasma levels of ChT, total acid phosphatase activity, ferritin and
globulin among GD not receiving ERT versus both GD on ERT and Control group. Positive
correlation between plasma ferritin and total acid phosphatase activity (r = 0.465 and P-value
<0.05).
Conclusions: Plasma ChT, total acid phosphatase activity; ferritin and globulin are collectively
helpful in evaluation and follow up the effect of ERT.