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Does vitamin D status correlate with insulin resistance in obese prediabetic patients? An Egyptian multicenter study

Research Authors
HelalF.Hettaa,b,∗∗,EmanM.Fahmyc,GhadaA.Mohamedd,MarwaA.Gabere,AzzaElkadyf, MohamedM.Elbadrg,IsraaM.S.Al-Kadm
Research Department
Research Journal
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Research Publisher
ELSEVIER SCI LTD
Research Rank
1
Research Vol
13
Research Website
NULL
Research Year
2019
Research_Pages
2813-2817
Research Abstract

Background The link between Vitamin-D deficiency and type 2 diabetes (T2D) is well-established. Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum levelofvitaminDandBMI,FBS,HOMAIRandHbA1camongprediabetespatients. Methods A multicenter case control study was carried out among 101 prediabetic persons & 50 controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D level, Plasma levels of glycosylated hemoglobin (HbA1c) and fasting insulin levels were measured by ELISA in bothgroupsenrolledinthestudy. Results The prevalence of vitamin-D deficiency/insufficiency was (73.3%) (n=74) among 101 prediabetic obese individuals. Also, A significant inverse correlation was observed between vitamin D levels & body mass index(r=- 0.28, P=0.004); fasting blood sugar (r=- 0.22, P=0.002); HOMA insulin resistance (r=0.25P=0.01);HbA1C(r=-0.2, 0.004). Conclusions High prevalence of vitamin D deficiency exists among obese prediabetic individuals and there is significantinversecorrelationbetweenBMI,FBS,HOMAIR,HbA1candvitaminDlevel