A 35 years old man present with a skin lesion on his glans complaining of mild irritation. The condition began 3 years ago, he took wrong medication as he was diagnosed as psoriasis, mostly because the disease in it the beginning is very similar and could trick the dermatologist. He was diagnosed by the biopsy taken,Pseudo-epitheliomatous hyperkeratotic and micaceous balanitis. 5-Flouracil was given in combination with oral Acitretin, Dramatic improvement occurred in both the skin lesion and the symptoms associated.