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Impact of oil type on the development and oral bioavailability of self-nanoemulsifying drug delivery systems containing simvastatin
Research Abstract
The aim of this work is to develop and evaluate self‑nanoemulsifying drug delivery systems (SNEDDS) containing simvastatin to increase its oral bioavailability. Formulation EO 5 (Ethyl oleate 9.3% w/w: Tween 80 49.4% w/w: Propylene glycol 39.3% w/w) and Formulation CL 14 (Clove oil 54.3% w/w: Tween 80 34.4% w/w: Transcutol‑P 9.3% w/w) were thoroughly studied. They showed emulsification time less than 1 min, droplet size in the nanometric range, and almost a complete drug release after 2 h. The in‑vitro dissolution profile of both formulations was found to be significant in comparison to the pure drug in pH 1.2 and 7.4 buffers (P < 0.0001). Furthermore, they demonstrated superior anti‑hyperlipidemic activity in comparison to simvastatin suspension (10 mg/kg/day). In order to investigate the impact of oil type on oral bioavailability, the selected formulations have been examined in terms of the in‑vivo pharmacokinetic study, and formulation EO 5 was found to have higher bioavailability. After oral administration of a single dose (40 mg/kg) of simvastatin‑loaded SNEDDS (CL14 and EO 5), a 1.5‑fold and 1.95‑fold increase in bioavailability were observed, respectively, as compared to simvastatin suspension. Hence, the results indicated that the developed SNEDDS could enhance the therapeutic efficacy and oral bioavailability of simvastatin.
Research Date
Research Department
Research File
s41598-024-71980-5 (2).pdf
(1.92 MB)
Research Journal
Scientific reports
Research Member
Research Publisher
Springer nature
Research Rank
Q2
Research Vol
14:22584
Research Website
https://www.nature.com/srep/
Research Year
2024
Announcement for Clinical Pharmacy Students – Class (10)The practical exam for the course "Drug Design"
The practical exam for Clinical Pharmacy students – Class (10)
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إعلانات الطلاب
Announcement for fifth-year Pharm D students: Practical exam for the optional course (Computer-aided Drug Design) will be held.
The practical exam for the elective course
"Computer-Aided Drug Design" for 5th-Year Pharm D students will be held in the computer labs
for Group (A) and Group (B) as follows:
|
Day |
Date |
Group |
Time |
|
Monday |
28/04/2025 |
Group (A) |
12:00 PM |
|
Tuesday |
29/04/2025 |
Group (B) |
12:00 PM |
All students must attend according to their assigned group and time.
No makeup exam will be given without an officially approved excuse.
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إعلانات الطلاب
Announcement for First-Year Pharm D and Clinical Pharmacy Students: The second-term mid-term exam and the theoretical and practical exam for the course "Pharmaceutical Organic Chemistry-2" will be held on Saturday, April 26, 2025.
The department announces that the second mid-term exam and the practical theory exam will be held on Saturday, April 26th, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Venue: Hall 2, beneath Lecture Hall B
Course Content for the mid-term Exam (10 Marks):
- Prof. Dr. Samia Galal Ahmed's section: “Aldehydes and Ketones” – Lectures 1 and 2
- Prof. Dr. Ola Ibrahim Abdel Razek's section: “Aliphatic and Aromatic Amines” – Lectures 1 and 2
Course Content for the Practical Theory Exam (15 Marks):
- All practical sessions
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قسم الكيمياء العضوية
Announcement for First-Year, Clinical Pharmacy, and National University Students: The second-term mid-term exam and the theoretical and practical exam for the course "Pharmaceutical Organic Chemistry-1" will be held on Sunday, May 4, 2025.
The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Exam Venues:
- Pharm D : Hall 1
- Pharm D National University: Hall 2
- Pharm D Clinical: Department Lecture Hall
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قسم الكيمياء العضوية
Announcement for National University First-Year Students: The practical exam for the course Pharmacognosy-1 will be held on Saturday, April 26, 2025.
The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Exam Venues:
- Pharm D : Hall 1
- Pharm D National University: Hall 2
- Pharm D Clinical: Department Lecture Hall
news category
خبر عام
Announcement for First-Year Pharm D Students: The practical exam for the course Pharmacognosy -1 will be held on Monday, April 28, 2025.
The Practical Exam for First-Year Students in the course Pharmacognosy (1) will be held on:
? Monday, April 28th, 2025
? Time: From 8:30 AM to 10:00 AM
? Location: Department Laboratories
Students will be distributed as follows:
|
Lab |
Floor |
Student Numbers |
Examples of Names |
|
Lab (A) |
4th Floor |
From 2241002 to 2241038 |
Abanoub Nasser Ibrahim – Joey Mokhtar Roshdy |
|
Lab (B) |
4th Floor |
From 2241040 to 2241070 |
Habiba Sayed Ahmed – Sohaila Khaled Ali Mohamed |
|
Lab (C) |
4th Floor |
From 2241073 to 2241111 |
Shahenaz Mohamed Ahmed Othman – Mohamed Yassin Mohamed |
|
Lab (D) |
4th Floor |
From 2241112 to 2241146 |
Mahmoud Abdelrahman Abdelrahman Mohamed Abdelkader |
|
Lab (B) |
3rd Floor |
From 2231005 to 2231110 |
Ahmed Fawzy Abdel-Aal – Mohamed Gamal Mohamed |
? Note:
- All students must attend in their assigned lab.
- The exam will not be repeated for any student who is absent without an officially accepted excuse by the faculty administration.
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إعلانات الطلاب
Announcement for National University Students: An exam for the course "Pharmacognosy-2" will be held on Tuesday, April 22, 2025
It has been decided to hold the practical exam for National University students (course Pharmacognosy -2) on Tuesday, April 22, 2025, at 10:00 AM in Lab (D), 4th floor.
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خبر عام
Announcement for Class (10) – Clinical Pharmacy Program it has been decided to hold the theoretical and practical exam for the "Phytotherapy" course on Sunday, April 27, 2025.
Phytotherapy Course – Theoretical and Practical Exam
For Clinical Pharmacy Students – Class (10)
The theoretical and practical exam for the Phytotherapy course will be held as follows:
? Date: Sunday, April 27, 2025
? Time: To be announced later
? Venue: Hall (2), beneath the lecture Halls
news category
إعلانات الطلاب