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Phytochemical investigation of Gardenia thunbergia L. f. aerial parts led to the isolation of a previously undescribed neolignan 13, designated (thunbergiside A). This compound is classified as 2,3-dihydrobenzofuran that features a unique, highly substituted skeleton with functional diversity. The absolute configuration was established by comparing its experimental ECD spectrum and optical rotation values with those of related neolignans. In addition, seventeen diverse phytoconstituents were identified for the first time from this plant, expanding our knowledge of its chemical composition. These included oleanane-type saponins, phenolic derivatives, lignans, and neolignans, which serve as valuable chemotaxonomic markers. Considering the frequent emergence of infectious diseases, it is worth exploring additional antimicrobial agents. Selected isolated compounds were assessed for their antimycotic properties in an investigation for potential anti-infective agents. Various chromatographic procedures, spectroscopic, spectrometric analyses, and molecular modelling studies were employed for phytochemical investigation and structural characterization. Furthermore, the alamarBlue-based viability assay was employed for antifungal evaluation against three pathogenic fungi. Specifically, saponin 17, 3-O-(β-ᴅ- glucuronopyranoside) oleanolic acid, displayed moderate antifungal activity (IC50 = 11 µg/mL) against Candida albicans. Overall, this study identified an unprecedented neolignan along with other diverse constituents from Gardenia thunbergia. Moreover, the study presented a potential scaffold for antifungal drug development.
God willing, the first seminar to rgister the master’s thesis for the pharmacist/
Mirna Gamal Khalaf Abdel Nasser
in the pharmaceutical sciences (pharmaceutical analytical chemistry)
will be held on Wednesday, April 3, 2024, at ten in the morning, in the meeting room on the fifth floor of Building (B) in the Faculty.
It was decided to hold a practical theoretical exam (sheet) on Thursday, April 18, 2024, from nine in the morning in the explanation hall on the third floor of the Pharmacognosy Department.
A practical theoretical exam for the third year for Phytochemistry-2 course will be held on Tuesday, April 23, at twelve noon.
The distribution of students is as follows:-
|
the name |
Place |
|
Abanoub Ashraf - Hasnaa Abdel Hafeez |
Laboratory (A), third floor |
|
Al-Shaima Ashraf - Rehab Abdo |
Laboratory (B), third floor |
|
Radwa Khaled - Safaa Hamd |
Laboratory (C), third floor |
|
Doha Nasser - Mahmoud Al-Badry |
Laboratory (D), third floor |
|
Mahmoud Khaled – to the end of the list |
Explanation amphitheater, the third floor |
The practical exam for the Phytochemistry-2 course - Semester (6) will be held Sunday, April 21, 2024, at twelve noon, and the students will be distributed as follows:
|
Place |
Numbers |
|
Laboratory A, third floor |
1-20 Ibrahim Muhammad - Devid Osama |
|
Laboratory B, third floor |
21 - 40 Omar Osama Othman- -Ruba Essam El-Din - |
|
Laboratory C, third floor |
41 - 60 Amr Mahrous -Moatasem Mohi El-Din - |
|
Laboratory D, third floor |
61-81 Makarios Rafiq - Ammar Yousry |
For students of the fifth level, Pharm D and Clinical, the Faculty’s internship pharmacists training unit announces the holding of an introductory meeting about the training program and answering students’ inquiries, on Sunday, April 21, 2024, at two o’clock in the afternoon, in Classroom A. All students must attend because of the importance
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Compulsory Training Unit (Internship)
