Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
The periodic exam for students of the National University, offered course, medicinal plants, will be held on Monday, March 25, 2024, in the laboratories of the third floor, Building (A), at eleven in the morning.
Modafinil (MOD) is a CNS stimulant used for the treatment of narcolepsy, shift work sleep disorder, excessive daytime sleepiness, and post-COVID 19 neurological symptoms. In the literature, there is no report of square wave voltammetric (SWV) methods being used for the determination of MOD. This study describes, for the first time, the construction and evaluation of the analytical performance of a novel sensor for ultrasensitive SWV detection of MOD. The sensor was constructed by integration of silver nanoparticles (AgNPs) on Mesna (MSN) layers over a pencil graphite electrode (PGE) surface. The interface and morphological characteristics of the fabricated AgNPs@MSN/PGE sensor were investigated via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). This sensor was found to enhance the electro-oxidation of MOD. The combination of AgNPs@MSN/PGE with SWV enabled the determination of MOD in its bulk form and in pharmaceutical and biological matrices at the nanomolar scale (LOD = 28.59 nM) with excellent recoveries. This study represents the first report describing an electrochemical procedure for MOD detection in human plasma. The established SWV method was also validated, and the results were consistent with ICH criteria. Finally, the presented SWV procedure provides a facile, sensitive, rapid, and cost-effective approach compared to other existing methods.
The produce of the Pharmacognosy Department’s farm will be sold on Sunday, March 24, 2024, from ten in the morning, at the sales outlet in the faculty:
Item price
Peppermint 2,25 LE
She mourns
The family of the Faculty of Pharmacy - Assiut University, its dear loss
Professor Dr
Hassan Hassan Ahmed Farag
Emeritus Professor in the Department of Pharmaceutical Medicinal Chemistry
The faculty family mourns his gentle character, generous assets, abundant knowledge, and dedication to performing his work. May God bestow his mercy on the deceased, place him in spacious gardens, and grant his family and relatives patience and solace. The faculty family also extends its sincere condolences and deep sympathy to the family of the deceased, his students, and his lovers. We belong to God and to Him we shall return.
The applications will be starts for postgraduate students
)PhD - Master - Doctor of Pharmacy - Diplomas)
Starting from March 20, 2024 until March 28, 2024
The periodic and theoretical practical exam for the course Pharmaceutical Medicinal Chemistry - 2 for clinical pharmacy students, semester (6),
will be held on Thursday, March 21, 2024, at 10:30 a.m. in the department’s auditorium and laboratories.
the periodic and practical sheet exams for the Pharmaceutical Chemistry 2 course for third-year Pharm-D students
will be held on Thursday, March 21, 2024, from twelve to one-thirty in the afternoon in Hall (2).
The mid-term exam for first-year students (Pharmacognosy1 course) will be held on Thursday, April 18, 2024, in Hall (1) from two to three p.m.
The practical and mid-term exams will be held on Thursday, March 28, 2024, from 9 to 10:20 a.m. in the C and D laboratories, third floor.
Trichinella spiralis infection is a food-borne zoonotic disease caused by nematodes
that dwell in the tissues, presenting a significant public health concern. This study
aimed to evaluate the effectiveness of different treatments including silver nanoparticles (AgNPs), myrrh biosynthesized AgNPs “AgNPs synthesized using plant-based
green technologies”, myrrh extract, and myrrh essential oil, as alternative treatments
against T. spiralis infection. Parasitological, histopathological, and cytotoxicity assessments were conducted to investigate the effects of various concentrations of these
treatments in reducing the populations of adult worms and larvae during both the
intestinal and muscular phases of T. spiralis-infected mice. The results showed that
the highest antihelminthic efficacy against the intestinal phase of T. spiralis was
achieved by myrrh extract (86.66%), followed closely by AgNPs (84.96%) and myrrh
AgNPs (82.51%) at higher concentrations (800 mg/kg for myrrh extract, 40 μg/mL
for AgNPs, and 40 μg/mL for myrrh AgNPs). While the group treated with myrrh
essential oil showed the lowest percentage of adult reduction (78.14%). However, all
treatments demonstrated comparable effects in reducing the larvae population in the
muscle phase. Histopathological examination of the tissues revealed compelling evidence of the effectiveness of AgNPs, particularly when prepared with myrrh. Additionally, a comprehensive assessment of the cytotoxicity of AgNPs indicated low
toxicity levels. This study supports that AgNPs synthesized using plant-based green
technologies hold therapeutic potential for the treatment of T. spiralis infection.
These findings present a promising avenue for the development of novel antiparasitic
drugs that are both effective and safe.
