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The promising antioxidant effects of lignans: Nrf2 activation comes into view

Research Abstract

Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several intriguing bioactivities, including anti-inflammatory, antioxidant, and anticancer activities. Nrf2 controls the expression of many cytoprotective genes. Activation of Nrf2 is a promising therapeutic approach for treating and preventing diseases resulting from oxidative injury and inflammation. Lignans have been demonstrated to stimulate Nrf2 signaling in a variety of in vitro and experimental animal models. The review summarizes the findings of fourteen lignans (Schisandrin A, Schisandrin B, Schisandrian C, Magnolol, Honokiol, Sesamin, Sesamol, Sauchinone, Pinoresinol, Phyllanthin, Nectandrin B, Isoeucommin A, Arctigenin, Lariciresinol) as antioxidative and anti-inflammatory agents, affirming how Nrf2 activation affects their pharmacological effects. Therefore, lignans may offer therapeutic candidates for the treatment and prevention of various diseases and may contribute to the development of effective Nrf2 modulators.

Research Authors
Emad H. M. Hassanein, Hanan S. Althagafy, · Mohammad A. Baraka, Esraa K. Abd‑alhameed, Islam M. Ibrahim, · Mostafa S. Abd El‑Maksoud, · Nesma M. Mohamed · Samir A. Ross,
Research Date
Research Department
Research Journal
Naunyn-Schmiedeberg's Archives of Pharmacology
Research Member
Research Publisher
Springer
Research Rank
Q2
Research Vol
397
Research Year
2024

The 17th edition of the "Step on the Road" conference was lunched, organized by the Egyptian Pharmaceutical Students Federation (EPSF Assiut).

 
Under the patronage of Prof. Dr. Ahmed El-Menshawy, President of the University, and Prof. Dr. Ahmed Abdel-Mawla, Vice President of the University for Education and Student Affairs, and under the supervision of Prof. Dr. Gehan Nabil Fattah, Dean of the Faculty, Prof. Dr. Hassan Refaat Hassan, Vice Dean for Education and Student Affairs, Prof. Dr. Hisham Mohamed Tawfik, Coordinator of Student Activities, Dr. Nermine El-Iraqi, Associate Professor of Pharmaceutics and Academic Supervisor of the Pharmaceutical Students Association, and Dr. Shaimaa Ali Abdel-Zaher, Director of Student Welfare at the Faculty, the 17th edition of the "Step on the Road" conference, organized by the Egyptian Pharmaceutical Students Federation (EPSF Assiut), was inaugurated.
The conference, which is being held over four days from February 3-6, 2025, features exceptional participation from pharmacy students from public, private, and national universities in Upper Egypt. The conference aims to develop students' skills and prepare them for the job market.
The opening took place on Monday, February 3, 2025, in the Prof. Dr. Mohamed Rafat Hall at the university’s administrative building.

 

https://www.aun.edu.eg/main/ar/jamt-asywt-ttlq-falyat-almwtmr-allmy-llathad-almsry-ltlab-klyt-alsydlt-khtwt-ly-altryq-fy-nskhth



افتتاح مؤتمر ( خطوة على الطريق ) فى نسخته السابعة عشر والذي ينظمه الأتحاد المصري لطلاب صيدلة  (EPSF Assiut)

افتتاح مؤتمر ( خطوة على الطريق ) فى نسخته السابعة عشر والذي ينظمه الأتحاد المصري لطلاب صيدلة  (EPSF Assiut)

افتتاح مؤتمر ( خطوة على الطريق ) فى نسخته السابعة عشر والذي ينظمه الأتحاد المصري لطلاب صيدلة  (EPSF Assiut)

افتتاح مؤتمر ( خطوة على الطريق ) فى نسخته السابعة عشر والذي ينظمه الأتحاد المصري لطلاب صيدلة  (EPSF Assiut)

افتتاح مؤتمر ( خطوة على الطريق ) فى نسخته السابعة عشر والذي ينظمه الأتحاد المصري لطلاب صيدلة  (EPSF Assiut)

 

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خبر عام

A seminar for pharmacist Arij Ali Ashour in order to obtain a Master's degree in Pharmaceutical Sciences (Pharmacognosy) on Thursday, February 6, 2025

God willing, on Thursday 6/2/2025, a seminar will be held in the Department of Pharmacognosy for the pharmacist / Arej Ali Ashour to obtain a master’s degree in pharmaceutical sciences (Pharmacognosy) the title: -

 

Pharmacological study of Enterolobium cyclocarbam (Jack. (Jacq.) Griseh family Fabaceae cultivated in Egypt

In the meeting hall of the Pharmacognosy Department at 11:00 am

 

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خبر عام

A seminar will be held on Thursday, February 6, 2025, to register the research topic for the Master's thesis of Pharmacist Martina Makram Ashm, a teaching assistant in the department

God willing, on Thursday February 6, 2025, a seminar will be held in the Department of Pharmacognosy to register the topic of the master’s thesis research of the pharmacist / Martina Makram Asham, a teaching assistant in the department, to obtain a master’s degree in pharmaceutical sciences (pharmacognosy), the title: -

Pharmacognostical and biological studies of the Caryota maxima L. Family: Arecaceae cultivated in Egypt

This will be in the meeting hall of the Pharmacognosy Department at exactly eleven o'clock in the morning.

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خبر عام

Announcement for Administrative Staff and Employees

 

The Student Computer Unit announces the holding of an exam for the training course titled (Basics of Word 2007) for the administrative staff and employees who missed attending the previous course at the Faculty. The exam will take place on Sunday, February 23, 2025, at 8:00 AM in the unit’s laboratories.
All nominated staff are required to attend

إعلان للإداريين والعاملين

 

 

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خبر عام

Carbon Nano-Dots based potentiometric sensor for the assay of the antiviral agent; Valacyclovir: In-Depth DFT Calculations, application to the pharmaceutical formulation and greenness assessment

Research Abstract

Valacyclovir (VAL), as a prodrug to acyclovir antiviral agent, has recently held a lot of interest for its efficacy boosting owing to the significant improvement in bioavailability. This makes it a successful candidate in the management of herpes simplex strains as well as CORONA viruses. In this work a carbon nano dot-modified glassy carbon electrode (GCE) has been optimized as potentiometric sensor for the assay of VAL through a systematic approach. A mixture components of polyvinyl chloride (PVC) membrane have been selected and fine-tuned for optimum sensitivity and selectivity. The best results have been obtained by drop casting a blend in % w/w of PVC; 30.85, tricrasyl phosphate (TCP) as plasticizer; 64.32, phosphotungstic acid (PT) as cation exchanger; 1.61 and phosphorus – nitrogen-doped carbon nano-dots (PNCDs); 3.22 over the GCE. The density function theory (DFT) calculations have been applied …

Research Authors
Ahmed Faried Abdel Hakiem, Ahmed Mohsen Kamal, Ahmed Safwat Aboraia, Refaat M Mahfouz, Ahmed AK Mohammed, Ibrahim A Naguib, Mohammed E Draz
Research Date
Research Journal
Microchemical Journal
Research Publisher
Elsevier
Research Vol
206
Research Year
2024

Meeting of the Libraries Committee of the College of Pharmacy and that will be on Monday, February 17, 2025

God willing, the meeting of the Libraries Committee at the College of Pharmacy and that will be on Monday, February 17, 2025, at ten in the morning at the invitation of Professor Mrs. Professor Dr. Gihan Nabil Hassan Fetih

This meeting will be held in the office of Mrs. Prof. Dr. / Dean of the College - Fifth Floor (Administrative Building).

 

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خبر عام

Meeting of the Executive Committee (Clinical Pharmacy Program) and that will be on Monday, February 17, 2025.

 God willing, the Executive Committee meeting and that will be on Monday, February 17, 2025, at 10:30 AM.

The meeting will take place in the Faculty Council Hall, 5th Floor (Administrative Building)

Dean of the Faculty

(Prof. Gihan Nabil Hassan Fetih)

 

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خبر عام

Announcement

The Student Computer Unit announces the holding of a training course on the basics of Word 2007 for administrative staff and employees who missed attending the previous course at the Faculty. The course will take place on Sunday and Monday, February 16-17, 2025, at 10:00 AM in the unit’s laboratories.
All nominated staff are required to attend.

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خبر عام
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