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Synthesis and characterization of new quinazolinylmethylsulfanylpyridines,
quinazolinylthieno[2,3-b]pyridines and pyrido[3’’,2’’:4’,5’]
thieno[3’,2’:4,5]pyrimido[6,1-b]quinazolines

مؤلف البحث
Yasser A. El-Ossaily,Elham A. Al-Taifi,Etify A. Bakhite,Islam S. Marae,Remon M. Zakic
*
ملخص البحث

Reaction of 2-chloromethylquinazoline-4(3H)-one with some 3-cyanopyridine-2(1H)-thiones gave the
corresponding thioethers which upon treatment with appropriate base, underwent intramolecular ThorpeZeigler reaction affording the isomeric 3-amino-2-(3,4-dihydro-4-oxo-2-quinazolinyl)thieno[2,3-b]pyridines. In
contrast, the reaction of 2-chloromethylquinazoline-4(3H)-one with 3-cyanoquinoline-(1H)-thione gave 3-
amino-2-(3,4-dihydro-4-oxo-2-quinazolinyl)thieno[2,3-b]quinoline directly. Reaction of the resulting
aminothienopyridines/quinoline with some reagents namely; acetic anhydride, triethyl orthoformate and/ or
nitrous acid were carried out and their products were identified

قسم البحث
مجلة البحث
Arkivoc
Archive for Organic Chemistry
المشارك في البحث
الناشر
https://www.arkat-usa.org.
تصنيف البحث
1
عدد البحث
NULL
موقع البحث
https://doi.org/10.24820/ark.5550190.p011.094
سنة البحث
2020
صفحات البحث
1-13