A lot of insecticides are found nowadays, but neonicotinoids are
considered the most famous. So, a series of pyridine derivatives neonicotinoids
analogues, namely, 3-cyano-4,6-dimethylpyridine-2(1H)-one (1), 2-chloro-3-cyano-4,6-
dimethylpyridine (2), 3-cyano-4,6-dimethylpyridine-2(1H)-thione (3), 3-cyano-4,6-
distyrylpyridine-2(1H)-thione (4), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)-N-phenylacetamide
(5), 3-amino-N-phenyl-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (6),
2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)-N-(p-tolyl)acetamide (7), 3-amino-4,6-distyryl-
N-(p-tolyl)thieno[2,3-b]pyridine-2-carboxamide (8), 2-((3-cyano-4,6-distyrylpyridin-
2-yl)thio)-N-(4-methoxyphenyl)acetamide (9), and 3-amino-N-(4-methoxyphenyl)-4,6-
distyrylthieno[2,3-b]pyridine-2-carboxamide (10), have been designed and synthesized in
pure state, and their agricultural bioefficacy as insecticides against cowpea aphid Aphis
craccivora Koch was screened. The structures of the synthesized compounds were verified
by means of spectroscopic and elemental analyses. Insecticidal bioefficacy data illustrated
that some compounds are excellent against cowpea aphid, and the bioefficacy of the rest of the tested compounds ranged from
good to moderate against the same insects.