One of the most impact issues in recent years refers to the COVID-19 pandemic, the consequences of which thousands of deaths recorded worldwide, are still inferior understood. Its impacts on the environment and aquatic biota constitute a fertile field of investigation. Thus, to predict the impact of the indiscriminate use of azithromycin (AZT) and hydroxychloroquine (HCQ) in this pandemic context, we aim to assess their toxicological risks when isolated or in combination, using zebrafish (Danio rerio) as a model system. In summary, we observed that 72 h of exposure to AZT and HCQ (alone or in binary combination, both at 2.5 μg/L) induced the reduction of total protein levels, accompanied by increased levels of thiobarbituric acid reactive substances, hydrogen peroxide, reactive oxygen species and nitrite, suggesting a REDOX imbalance and possible oxidative stress. Molecular docking analysis further supported
ملخص البحث
تاريخ البحث
قسم البحث
مجلة البحث
Journal of Medical Entomology
المشارك في البحث
الناشر
Elsevier
تصنيف البحث
1
عدد البحث
790
موقع البحث
https://www.sciencedirect.com/science/article/pii/S0048969721032009
سنة البحث
2021
صفحات البحث
148129