he efficiency of azadirachtin, jojoba oil, Reynoutria sachalinensis, azoxystrobin + difenoconazole, kresoxim methyl, propiconazole and sulphur in controlling powdery mildew disease of Grapevines caused by Uncinula necator (Schlecht.) was evaluated during 2015 and 2016 seasons. Laboratory study showed that all the tested plant extracts and fungicides significantly (p < 0.05) reduced germination of conidia of the causal pathogen. Spraying of the extracts on vine trees significantly (p < 0.05) decreased the disease severity (D.S. %) compared with infected control. The tested plant extracts as well as fungicide have high effect in disease reduction; no significant differences (p < 0.05) in the disease reduction were found in the effect of the extracts between tested compounds in both seasons. Moreover, treatment of trees with Reynoutria extract exhibited the highest increment in peroxidase activity (PO), polyphenol-oxidase (PPO) activity and phenol content compared to other treatments after 9 days from spraying.