This study was carried out at the Experimental Orchard, Faculty of Agriculture, Assiut University, Egypt, to study the effect of GA3, calcium chloride and vapor guard spraying on fruiting of Manfalouty pomegranate during 2014 and 2015 seasons. The experiment was set up in a complete randomized block design with three replicates, one tree per each. GA3, calcium chloride and vapor guard spraying significantly increased the yield/tree compared to unsprayed ones. GA3 spraying gave the highest yield followed by calcium chloride. On the other hand, all treatments significantly decreased the fruit cracking percentage compared to unsprayed ones. The least fruit cracking was recorded due to calcium chloride spraying. All treatments significantly increased fruit weight and fruit dimensions as well as aril percentage and juice contents compared to unsprayed ones. Moreover, calcium chloride and vapor guard significantly improved the fruit chemical constituents, whereas, GA3 spraying decreased the chemical fruit constituents compared to unsprayed ones. It could be concluded that spraying Manfalouty pomegranate trees with calcium chloride at 40 or 80 ml/L at 1 st July was necessary to get high yield, reduce the fruit cracking percentage and improve fruit quality