Field experiment was conducted at Shandweel Agricultural Station, Sohag Governorate in Upper Egypt during 2015 and 2016 seasons to study the effect of using some simulative substances on growth and productivity of Egyptian cotton cultivar (Giza 90) under late plantings in Upper Egypt. The experimental design was a randomized complete block designee using split plot arrangement with four replications. The Main plots included two planting dates (early in 1st March and late in 1st April) and sub plots included simulative substances (mineral, organic and biotic ) application namely: Silicate 7.5 cm3/L, Lithovit (CO2) 5g/L, Humic acid 5cm3/L, Mix of organic acids (citric 500 ppm, ascorbic 300 ppm and salicylic 200 ppm), Potassiomage 1kg/fed. and Mycorrhizae 4cm3/L with control (untreated plants). The combined analysis between years was done. Obtained results revealed that: Years affected significantly all characters under this study due to the variation in total amount of heat units, which was higher in 2016 growing season than 2015 season, this led to significant increase in vegetative growth (plant height and no. of fruiting branches/plant) as well as its caused decrease in most studded traits. Early planting significantly increased no. of fruiting branches/plant, no. of open bolls /plant, boll weight, seed index, seed cotton yield/fed. and fiber quality compared with the late planting date. Simulative substances application affected significantly plant height, number of fruiting branches /plant, number of open bolls /plant, boll weight, seed index, seed cotton yield /fed. and fiber quality. Plants sprayed with Humic acid gave the highest averages of these traits followed by plants sprayed with Silicate then plants sprayed with Lithovit. The interactions between years × planting dates and years × simulative substances had a significant effect on growth, yield and fiber quality under this study. Moreover, the interaction between planting date × simulative substances had significant effect on growth, yield and fiber quality. Also, the interaction between years × planting dates × simulative substances had significant effect on growth, yield and fiber quality. Simulative substances (mineral, organic and biotic) application to plants under early and late planting date had positive effects on improving the performance of cotton plants, which increased plant growth and yield especially under late planting.