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Hepato-morpholoy and biochemical studies on the liver of albino rats after exposure to glyphosate-Roundup®

Research Authors
Shaimaa M. M. Saleh , Tasneem A. Elghareeb , Mohamed A. I. Ahmed , Ibrahim A. Mohamed , Hosam A. Ezz El-Din
Research Abstract

Background: The object of this work was to evaluate of the hepatic effects of the herbicides glyphosate-Roundup®
by different doses in both sexes of albino rats.
Methods: Forty animals divided into four groups with ten animals for each (both sexes) were treated orally with
vehicle (controls) and 25, 50, and 100 mg/kg bwt of glyphosate-Roundup® (treated groups) for 15 days daily.
Results: The most conspicuous changes occurred on the liver treated groups due to glyphosate toxicity were the
increase of enzymes activities of ALT and AST, cellular infiltration, many signs of nucleus degeneration, focal
necrosis, rarified cytoplasm, disorganization of cellular organelles, and deposition of lipid droplets. The increase in
the amount of collagenous fibers and the number of the mast cell were also observed.
Conclusion: Our results indicated that the administration of glyphosate-Roundup® in different doses may cause
adverse effects on the histopathological, ultrastructure, and biochemical alternations on the liver of the albino rats.

Research Department
Research Journal
The Journal of Basic and Applied Zoology
Research Member
Research Publisher
Springer
Research Rank
1
Research Vol
79(48)
Research Website
https://basicandappliedzoology.springeropen.com/articles/10.1186/s41936-018-0060-4
Research Year
2018
Research Pages
1-11