Yield performance of 30 F1 grain sorghum crosses, their parents along with two local check varieties was evaluated under two water regimes during summer seasons 2014 and 2015 at two locations represent clay and sandy soil in Egypt. Entries were watered each 14 days (surface irrigation in the clay soil) and for 2 hours each 3 days (drip irrigation system in the sandy soil) to obtain well-watered conditions. While the third and the fifth irrigations were skipped in the clay soil and entries were irrigated for 1 hour each 3 days to induce drought stress conditions. Nine drought tolerance indices namely; mean productivity (MP), geometric mean productivity (GMP), harmonic mean (HM), drought resistance index (DRI), yield index (YI), stress tolerance index (STI), tolerance index (TOL), stress susceptibility index (SSI) and standard drought tolerance index (SDTI) were calculated based on yield under well-watered (Yp) and drought conditions (Ys). The analysis of variance showed highly significant differences among genotypes for Yp and Ys and for all drought tolerance indices, suggesting that genotypes were differing in the performance under both treatments for grain yield and drought tolerance indices. Three groups contained the same genotypes were obtained by principal components and cluster analyses. These groups were described as tolerant, sensitive and semi-tolerant to drought. Significant correlation was observed between Yp and Ys and each of MP, GMP, HM, DRI, YI and STDI. Results indicated that selection based on combinations of drought tolerance indices such Ys, MP, STI and TOL was beneficial to identify drought tolerant genotypes. In hybrid programmes, it would be better to select genotypes based on their combining ability effects along with the reliable drought tolerance indices.