Tree vegetative growth, leaf mineral contents, yield compo-nents and fruit quality of three grapefruit cultivars namely, March, Red Blush and Ruby Red were studied under upper Egypt conditions during three successive seasons, 2009, 2010 and 2011. The results of this investigation could be summarized as follow: There was a great variability in vegetative growth traits, yield components and fruit quality of these cultivars. March grapefruit trees cultivar surpassed in vegetative growth and vigour compared to either Red Blush or Ruby Red trees cultivars. Also, March grapefruit cultivar was superior among the other cultivars in inducing the highest fruit set, largest fruit number and con-sequently the heaviest yield/tree. On the other hand, Red Blush grapefruit trees were superior in fruit quality and followed by the Marsh tree cultivar in its vegetative growth and productivity. On the account of the present findings, it can be concluded that March or Red Blush trees cultivars under this conditions gained the highest yield with good fruit quality