The pomegranate butterfly, Virachola livia (Klug) (Lepidoptera: Lycanidae), is one of the most important pests in Egypt. Under pomegranate field conditions, the study was conducted from 2012 to 2013 to compare the efficacy of methoxyfenozide, pyridalyl and emamectin benzoate against pomegranate butterfly in cultivated and reclaimed lands at Assiut Governorate, Egypt. These insecticides demonstrated a significant low infestation of the pomegranate butterfly during 2012 and 2013 seasons compared to control field. Emamectin benzoate and pyridalyl were found to be highly effective for controlling V. livia with an average infestation of 0.33- 4.33% and 1.00- 6.67% compared to methoxyfenozide (0.33- 17.67%) in both cultivated and reclaimed lands, respectively. Data indicated that, the infestation was higher in the cultivated land than reclaimed land during 2012 and 2013 seasons. The change in temperature and relative humidity may affect the susceptibility of pomegranate fruits to the infestation by V. livia. In addition, results showed that all pomegranate trees under treated field had a significant increase in the average weight fruits by about 70-90% compared to control field. Methoxyfenozide, pyridalyl and emamectin benzoate can be considered as promising candidates to control the pomegranate butterfly, V. livia infestation in both cultivated and reclaimed lands.