In order to study the effect of foliar spray by antioxidant (salicylic and ascorbic acids) and intercropping patterns on the production of both maize and soybean. Two field experiments were conducted at Agronomy Department Farm, Agriculture Faculty, Assiut University, Assiut, Egypt during 2016 and 2017 seasons. Two factors were studied, the first one was foliar application of Antioxidant compounds (control, ascorbic acid at 200 ppm, salicylic acid at 200 ppm and ascorbic acid + salicylic acid at 200 ppm). Four intercropping patterns were used (maize-soybean 2:2, maize-soybean 2:1, sole maize and sole soybean) as a second factor. The obtained results showed that: The results indicated that foliar spraying with antioxidant and intercropping patterns enhanced significantly all traits in this study except plant height of maize in both seasons. Thus, the highest values of measured traits where observed from plants which sprayed with salicylic acid at rate of 200 ppm of the two crops in the two successful seasons. Maximum yield and its attributes of maize were produced from the sole maize sown followed by the intercropping pattern of 2:1 of maize and soybean in both seasons. In addition, maximum soybean yield and its related traits were produced from the sole sown followed by the intercropping pattern 2:2 of maize and soybean in both seasons. It could be concluded that intercropping pattern 2:2 of maize and soybean with foliar spraying salicylic acid at rate of 200 ppm recorded the maximum of land equivalent ratio (LER) and monetary advantage index (MAI) of the unit area under Assiut Government condition.