Allergic diseases, derived from the dysregulation of immune tolerance mechanisms, have been
rising in the last two decades. Recently, increasing evidence has shown that probiotic-derived
polysaccharide capsules exhibit a protective effect against allergic diseases, involving regulation
of Th1/Th2 balance, induction of differentiation of T regulatory cells and activation of dendritic
cells (DCs). DCs have a central role in controlling the immune response through their interaction
with gut microbiota via their pattern recognition receptors, including Toll-like receptors and C-typelectin receptors. This review discusses the effects and critical mechanism of probiotic-derived
polysaccharide capsules in regulating the immune system to alleviate allergic diseases. We first
describe the development of immune response in allergic diseases and recent relevant findings.
Particular emphasis is placed on the effects of probiotic-derived polysaccharide capsules on allergic
immune response. Then, we discuss the underlying mechanism of the impact of probiotic-derived
polysaccharide capsules on DCs-mediated immune tolerance induction.
Research Abstract
Research Date
Research Department
Research Journal
Critical Reviews in Food Science and Nutrition
Research Member
Research Publisher
Taylor & Francis
Research Vol
63
Research Website
https://doi.org/10.1080/10408398.2022.2062294
Research Year
2023
Research Pages
8768–8780