This study responds to recent calls for research on how and why ethical leadership is related to employee outcomes. Drawing on self-concept–based theory and substitutes-for-leadership theory, the study examines both the mediating and moderating role of work meaningfulness on the relationship between ethical leadership and work engagement. Using a sample of Egyptian public hospital nurses, the results of structural equation modeling (SEM) revealed that work meaningfulness partially mediated the relationship between ethical leadership and engagement. Furthermore, the results showed the positive relationship between ethical leadership and work engagement was stronger for employees who experienced lower rather than higher levels of meaningfulness. Thus, public sector organizations need to put emphasis on nurturing ethical leadership and stimulating employees’ sense of work meaningfulness