Mindfulness includes individuals' opinions, feelings, and objective observations. The present study aimed at examining the factor structure and reliability of the Five-Facet Mindfulness Questionnaire for the Egyptian culture and investigating the relationship between mindfulness and thought fusion beliefs. This descriptive, cross-sectional and psychometric study was conducted on 507 university students (241 males, 266 females) from Assuit City, Egypt, selected using the available sampling method in 2018. The Principal Axis Factoring Approach to Exploratory Factor Analysis (EFA), the confirmatory factor analysis, concurrent validity and the relationship between mindfulness and depression were conducted to examine the validity of the Five-Facet Mindfulness Questionnaire. Criterion validity was verified using correlations with BDI-II, TF, SA, CERS and CSC to calculate the reliability and validity of the Five-Facet Mindfulness Questionnaire. Cronbach’s alpha and Composite reliability were employed. Statistical analysis was performed with SPSS version 23 and LISREL 8.8. The results of the EFA suggested five factors for this scale labelled as “observing” “describing” “acting with awareness” “non-judging of inner experience” and “non-reactivity to inner experience”. The reliability of this scale was good, and the correlation between mindfulness and depression was negative and significant in the following two facets: (acting with awareness, non-judging of inner experience). The results of the study also showed that the dimensions of observation and description were positively correlated with thought fusion beliefs, while the dimensions of non-judgment and acting with awareness were negatively associated with thought fusion beliefs.