In the hot desert climate zones, the energy consumption of fully glazed office buildings is too high due to the heavy cooling loads. This problem forced architects to use the High-Performance Glazing Systems (HPGSs) which reduce the solar heat gain and save energy. Despite the high initial cost, the HPGSs are supposed to be economically feasible in the long term. This study investigates and compares the economic feasibility of three HPGSs for an office building in New Cairo. In terms of life cycle cost (LCC), the Low-E, Electrochromic, and Photovoltaic glazing systems are compared to the Clear Double-Glazing as a conventional system. Furthermore, the three economic indicators; Net Present Value (NPV), Internal Rate of Return (IRR), and Payback Period (PBP) are analysed. In conclusion, the Low-E Glazing System has the lowest LCC because of the low disposal cost. Moreover, the Low-E glazing has the highest NPV, IRR, and the shortest PBP (15 years). Due to the high initial and maintenance costs, the Photovoltaic Glazing System has a higher LCC. The Electrochromic Glazing System is not economically feasible due to the highest LCC, the lowest NPV, the lowest IRR, and the longest PBP which exceeds 30 years.