The Superpave mix design system integrates material selection and mix design into procedures based on the project's climate and design traffic. Superpave uses a completely new system for testing, specifying, and selecting asphalt binders. While no new aggregate tests were developed, current methods for selecting and specifying aggregates were refined and incorporated into the Superpave mix design system. Performance testing uses new equipment and procedures to ensure that Superpave mixtures exhibit acceptable amounts of the distress types considered by Strategic Highway Research Program (SHRP) researchers: permanent deformation, fatigue cracking, and low temperature cracking. Moisture damage is weakens the adhesiveness and cohesiveness of the Asphalt Concrete (AC) due to the following attributes: (1) The material properties of the aggregate in terms of mineralogy, external compounds, moisture content, and surface roughness. (2) The material properties of the binder in terms of permeability and chemical composition. (3) The mixture properties in term of void structure, aggregate gradation, and binder content. (4) Additional causes such as environmental conditions, traffic volume and loads, pavement design, and construction practices (Sebaaly 2007). Surface Free Energy (SFE) is a method to evaluate asphalt concrete’s susceptibility to moisture damage. Liquid anti-strip agents and chemical lime additives have been used to reduce the susceptibility of the asphalt concrete to moisture damage. Chemical, wax or other organic additives, and foaming technologies obtained by means of special bitumen modifiers, represent a promising technical solution to reduce the temperatures required for warm mixtures asphalt production and pavement construction. Nanotechnology has the potential to create many new materials and devices with wide-ranging purposes. Nanomaterials are generally important modifiers in improving pavement performance, nanoclay, carbon nano tubes, nanosilica, nano-hydrated lime, nano-sized plastic powders, or polymerized powders, and nano fibers.