In this study, we present exact and heuristics algorithms for a traffic sensors location problem called the screen line problem. It is a problem of how to locate traffic sensors on a transportation network where all the origin/destination node pairs are fully separated. The problem experiences two main complexity dimensions that obstruct finding an efficient solution algorithm for large-scale networks: its mathematical formulation, which is proved in the literature to be NP-hard, and an inherent combinatorial complexity due to the need for a network complete path enumeration. In this study, the problem is reformulated as a set covering problem. Thereafter, the dual formulation is recalled showing that the shortest path-based column generation method would yield as many paths as necessary and hence circumvent the intractability of the full path enumeration task. This path generation technique enables applying both the proposed heuristics and exact methods to the problem. In addition, the gap value between the heuristics and the exact algorithms is set to be examined statistically. For evaluation, three networks of different sizes were used to track the scalability of proposed algorithms. The methodology showed high efficiency to deal with up to 10,000 demand node pairs in addition to the capability of producing practical solutions with respect to normal traffic flow conditions. The proposed heuristics algorithm stipulates a gap value of less than 25% with more than 99% confidence.