Skip to main content

Does vitamin D status correlate with insulin resistance in obese prediabetic patients? An Egyptian multicenter study

مؤلف البحث
HelalF.Hettaa,b,∗∗,EmanM.Fahmyc,GhadaA.Mohamedd,MarwaA.Gabere,AzzaElkadyf, MohamedM.Elbadrg,IsraaM.S.Al-Kadm
مجلة البحث
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
المشارك في البحث
الناشر
ELSEVIER SCI LTD
تصنيف البحث
1
عدد البحث
13
موقع البحث
NULL
سنة البحث
2019
صفحات البحث
2813-2817
ملخص البحث

Background The link between Vitamin-D deficiency and type 2 diabetes (T2D) is well-established. Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum levelofvitaminDandBMI,FBS,HOMAIRandHbA1camongprediabetespatients. Methods A multicenter case control study was carried out among 101 prediabetic persons & 50 controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D level, Plasma levels of glycosylated hemoglobin (HbA1c) and fasting insulin levels were measured by ELISA in bothgroupsenrolledinthestudy. Results The prevalence of vitamin-D deficiency/insufficiency was (73.3%) (n=74) among 101 prediabetic obese individuals. Also, A significant inverse correlation was observed between vitamin D levels & body mass index(r=- 0.28, P=0.004); fasting blood sugar (r=- 0.22, P=0.002); HOMA insulin resistance (r=0.25P=0.01);HbA1C(r=-0.2, 0.004). Conclusions High prevalence of vitamin D deficiency exists among obese prediabetic individuals and there is significantinversecorrelationbetweenBMI,FBS,HOMAIR,HbA1candvitaminDlevel