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Derangement of Basic Amino Acids and Nitric Oxide Levels in Patients Undergoing Cardiothoracic Surgery

مؤلف البحث
Ahmed Farouk1, Rasha A.Hamed2, Nashwa Farouk Abd El Hafez3, Rania N. Abdalla4, Farag M. Moftah5, Fify Alfy Gabra6,8 and Tahia H. Saleem7,8
تاريخ البحث
مجلة البحث
Journal of Cellular & Molecular Anesthesia (JCMA)
المشارك في البحث
الناشر
Journal of Cellular & Molecular Anesthesia (JCMA)
عدد البحث
8(2)
موقع البحث
https://doi.org/10.22037/jcma.v8i2.38772
سنة البحث
2023
صفحات البحث
84-94
ملخص البحث

Background: A cyclic relationship exists, between; arginine, citrulline, and ornithine. Arginase is a specific enzyme that plays a role in this relationship. These basic amino acids have a role in the induction of nitric oxide (NO) and as anti-inflammatory and antioxidant. This study aimed to elucidate the role of surgical injuries and anesthesia on plasma levels of the above-mentioned amino acids and NO and to determine whether the changes in these levels can be correlated to the duration of surgery and anesthesia exposure.
Materials and Methods: The study included: group A (41 patients) who underwent coronary bypasses and group B (17 patients) who underwent lung cancer surgery. An amino acid analyzer was used for the detection of amino acids, while NO was estimated by a Spectrophotometric method.
Results: The study revealed a significant decrease in the intra-operative levels of arginine, citrulline, ornithine, and NO compared to their pre-operative levels in both groups.
Conclusion: Depletion of these basic amino acids is possibly multifunctional and can be associated with an increase in arginase, surgical trauma, anesthesia, and stress.