Introduction: Pulmonary embolism (PE) remains under-diagnosed fatal disease at the emergency units suggesting the need for alternative, easy, noninvasive bedside diagnostic approaches. Objectives: The aim of this study was to determine the diagnostic role of transthoracic ultrasonography (TUS) and echocardiography in PE. Also, to evaluate if there is any additive diagnostic value of Color Doppler over gray-scale TUS in PE. Methods: Blinded to 64 multi-detectors CT pulmonary angiography (MDCTPA) examination as a gold standard, 60 patients with clinically suspected PE underwent gray-scale and Color Doppler TUS examination in addition to echocardiography. Results were compared and diagnostic accuracy of different techniques were assessed. Results:According to Modified Wells Score, 42 (70%) of the cases were defined as moderate risk for PE and 18 (30%) were defined as high risk. In 33 patients out of 40 MDCTPA proved cases of PE, TUS demonstrated 66 lesions with mean (SD) 2±1.20 lesion /patient."Consolidation with little perfusion sign" as detected by colour doppler TUS is helpful in differentiating PE from other peripheral lesions. Using echocardiography, signs of acute right ventricular strain with negative TUS and postive MDCTPA was found in 6 out 7 patients. For Gray-scale TUS, sensitivity, specificity, positive and negative predictive values and accuracy were 82%, 90%, 94%, 72% and 85%, meanwhile color Doppler TUS had values of 80%, 95%, 97%, 70.4% and 87.5%, respectively.. Conclusions: TUS combined with echocardiography is a reliable screening technique for diagnosing PE with high specificity and fair sensitivity. Adding Color Doppler to Gray-scale TUS increases the specificity and consequently the confidence in the diagnosis of peripheral pulmonary infarctions and differentiates them from other pulmonary lesions allowing its use as bedside screening technique in emergency-based situations especially for critically ill and immobile patients that allows initiation of anticoagulants