Background and Purpose: To detect sensitivity and specificity of diffusion-weighted imaging (DWI) as a non-invasive technique in the detection of de-novo cases of cancer larynx
Patients and methods: Patients included in this research were patients suspected of de-novo cancer larynx; This study is a prospective randomized comparative clinical trial.
Results: The mean apparent diffusion coefficient (ADC) of laryngeal lesions (0.73± SD 0.23 x10-.3 mm2) was lower (p < 0.001) than the mean of the normal part of the larynx in the same patients (1.09± SD 0.099 x 10-.3 mm2), The cut-off value of the ADC using receiver operating characteristics was Conclusion: DWI is an easily reproducible and non-invasive technique that can accurately explore the larynx and became a very important diagnostic tool of laryngeal diseases. This study demonstrated the cut-off point of ADC value for discrimination of malignant lesion is <0.87x 10-.3 mm2/s with restricted diffusion in DWI images.