Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer

Faculty of Medicine

Assiut University

Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer

Research Authors
Nivin A Hassana, Naglaa K Idrissb, Noha Gaberc, Abeer Ibrahimd, Mariana A Tawfeeka, Eman Mossadc, Aliaa A Mosab, Eman H Ahmedc, Sally A Sayede, Heba A Ahmedf, Amal AM Mohamedb
Research Date
Research Department
Department of Biochemistry
Research Journal
Cell Physiol Biochem
Research Member
Naglaa Kamal Idriss
Amal AbdelFattah Mahmoud Mohamed
Research Publisher
Cell Physiol Biochem
Research Vol
56
Research Website
https://articles.cellphysiolbiochem.com/Articles/000509/PDF/000509.pdf
Research Year
2022
Research_Pages
12
Research Abstract

Genetic alterations, including changes in the expression of spastic paraplegia 20 (SPG20) and serine/threonine protein kinase 31 (STK31), may play an important role in the carcinogenesis of colorectal cancer (CRC). Identification of such changes is suitable for the recognition of tumors at an early stage, which would significantly improve patient survival. While recent studies have identified that SPG20 and STK31 expression levels increase in CRC tissues, their use as a biomarker is yet to be investigated. Our aim was to determine whether circulating SPG20 and STK31 mRNAlevels could help distinguish between patients with CRC and healthy individuals. Additionally, we aimed to analyze the correlation between SPG20 and STK31 expression patterns and the tumor stage in patients with CRC.