Anti-Müllerian hormone is a predictor of medium-term cumulative live birth following in vitro fertilization/intracytoplasmic sperm injection: A retrospective study

Faculty of Medicine

Assiut University

Anti-Müllerian hormone is a predictor of medium-term cumulative live birth following in vitro fertilization/intracytoplasmic sperm injection: A retrospective study

Research Authors
Dang Kien Nguyen, Sean O'Leary, Moustafa Abdelhafez Gadalla, Bronnie Roberts, Helen Alvino, Kelton P Tremellen
Research Date
Research Department
Department of Obstetrics and Gynecology
Research Journal
European Journal of Obstetrics & Gynecology and Reproductive Biology
Research Member
Moustafa Ahmed Abdelrahman Abdelhafez
Research Publisher
Elsevier
Research Year
2022
Research Abstract

Objectives

This study aims to examine the capacity of anti-Müllerian hormone (AMH) to predict cumulative live birth rate (CLBR) following IVF/ICSI within 36 months since start of treatment.

Study design

This is a cohort study of women seeking IVF/ICSI fertility treatment in a private Australian IVF clinic in a single calendar year. Live births were monitored over three years following start date of IVF/ICSI. The impact of serum AMH level on the CLBR was assessed using Cox’s proportional hazard models, and its incremental values in the prediction of CLBR were evaluated.

Results

The CLBRs were significantly higher in women with AMH levels in the highest (>44.5 pmol/L; 87.0%, 95% CI 79.2% – 95.1%) and in the middle two quartiles (between 11.5 and 44.5 pmol/L; 81.0%, 95% CI 74.2% – 87.6%), compared with AMH levels below the 25th percentile (≤11.5 pmol/L; 63.2%, 95% CI 53.2% – 74.5%). Approximately half of …