The effect of nonalcoholic fatty liver disease (NAFLD) on outcome of patients with ST‑segment
elevation myocardial infarction is controversial. The purpose of the study aimed to assess the
effect of NAFLD on myocardial and epicardial reperfusion after primary percutaneous coronary
intervention (PPCI) among nondiabetic patients.
Patients and methods
A total of 240 nondiabetic patients with ST‑segment elevation myocardial infarction were
recruited and underwent PPCI. After revascularization, epicardial reperfusion had been
assessed by thrombolysis in myocardial infarction (TIMI) flow grades and TIMI frame
count, and myocardial reperfusion had been assessed by TIMI myocardial perfusion grade
and ST‑segment resolution. NAFLD had been assessed and graded based on abdominal
ultrasonography and then the patients were subdivided into NAFLD group (111 patients) and
non‑NAFLD group (129 patients).
Results
The overall prevalence of NAFLD in the current study was 46.5%. Clinically, KILLIP class more
than I was significant in NAFLD group [24 (P < 0.001)]. Multivessel coronary artery disease was
significant in NAFLD group [63 (56.8%) vs. 23 (17.8%); P < 0.001]. Eleven patients of NAFLD
group died, whereas no deaths occurred in the other group. Postprocedural myocardial blush
grades 0 and 1 were significant in patients with NAFLD group (P < 0.001). Moreover, absent
ST‑segment resolution and TIMI frame count were significant (P < 0.001) in NAFLD group.
Finally, NAFLD was an independent predictor for in‑hospital and follow‑up cardiac events.
Conclusions
NAFLD is considered an independent risk factor for the occurrence of in‑hospital and follow‑up
adverse cardiac events after PPCI in nondiabetic patients.