Purpose: To highlight the anterior chamber parameters changes after pars plana vitrectomy with silicone oil tamponade by Scheimpflug imaging. Methods: A prospective observational study was conducted on 20 patients (20 eyes) who had PPV for various indications. Using Scheimpflug imaging, all participants were assessed before PPV with Silicone oil tamponade and 1 week after the surgery to demonstrate the changes in AC parameters. The primary outcome measure was the change in central AC depth, while the secondary outcome measures were the changes in peripheral AC depth, AC volume, and anterior chamber angle. Results: There was a statistically significant reduction in CACD and Average PACD compared with the preoperative values (P=0.013 and <0.001, respectively). Moreover, there was a significant moderate positive correlation between AvPACD difference and preoperative AvPACD (r=0.512, P-value<0.001). There was a significant reduction in mean ACV compared with the preoperative value (P=0.010). There was a significant, strong positive correlation between ACV difference and preoperative ACV (r=0.742, p value <0.001). The mean ACA was 36.96°±12.89° preoperatively and decreased to 33.90°±8.44° one week postoperatively. However, this change was not statistically significant (P=0.293). There was a statistically significant strong positive correlation between ACA difference and preo perative ACA (r=0.781, p-value<0.001). Conclusion: Silicone oil tamponade with PPV induces significant short-term alterations in anterior chamber parameters, particularly a reduction in anterior chamber depth and volume. A comprehensive understanding of these parameter variations is essential for effective postoperative management.