Abstract: A 57-year-old man was referred for an fluoro-deoxy-glucose
positron emission tomography/computed tomography (F-18 FDG PET/CT)
study of a primary tumor after a poorly differentiated carcinoma with
neuroendocrine features which was biopsied from the liver. A 4-phase
abdominal CT showed a large liver right lobe mass, suspicious for hypovascular
hepatocellular carcinoma. Esophagogastroduodenoscopy and endoscopic
ultrasound showed normal findings. Colonoscopy revealed a benign
sigmoid colon polyp. PET/CT showed FDG avid bilateral hepatic lobe
lesions, disseminated bone lesions, and an intense focus in the prostate
suspicious for a prostatic primary. However, PSA was within the normal
range. Tissue sampling of the prostatic lesion revealed small cell carcinoma
with neuroendocrine features.