Background: The post anesthesia nurse assumes important for the care and clinical stabilization of the patient in the immediate postanesthetic phase one period until they are fit. Aim this study was carried out to investigate the effect of nursing care guidelines for postanesthetic (phase one) on patient outcome. Tools three tools were utilized to collect data pertinent to the study, which is Tool I Patients assessment sheet consists of three parts. Tool II Richmond Agitation Sedation Scale. Tool III faces pain scales. Methods a quasi-experimental design. The sample was (102) patients that divided into two groups (control 51 and study 51) collected over sixth months. Results As regarding to all time intervals hemodynamic parameters, respiratory status and immediately post anesthesia pain related operation there were statistically significant difference (p < 001) between control and study groups post anesthesia phase one, also As regard post-anesthesia complication reduce with statistically significant difference relation to airway obstruction, pain related operation and hypothermia (p < 0.009, p=0.029 and p=0.017) respectively between both groups. Conclusion apply nursing care guideline for post-anesthetic showed statistically significance difference of hemodynamic parameters, respiratory status outcomes, decrease pain level and complication.