Quality of life (QoL) is often severely impaired in people with schizophrenia, and compliance to antipsychotic medication has been consistently found to be low in these people. Aim of the study to assess quality of life and its relation with treatment compliance among schizophrenic patients. Subjects & Method: A descriptive correlational research design was used in this study. Purposive sample was utilized, consisting of 110 patients who have schizophrenia and accepted to share in this study. Tools of the study include personal data, World Health organization Quality of Life Scale and Medication Adherence Rating Scale. Results: The majority of schizophrenic patients had fair level of quality of life and more than half of them are non-adherent with medication. A highly statistically significant difference was found between quality of life and medication adherence. The study Concluded that the majority of schizophrenic patients had fair level of quality of life and a highly statistically significant relation was found between quality of life and medication adherence (P=0.012(. Recommendation: Further studies are needed to investigate non compliance factors on larger sample size in different settings and different tools.