Background: Leveraging Decision Support Systems (DSS) enhances nurses' access to tacit knowledge, eventually enhancing the quality of their strategic decision-making in patient care. Aim: To investigate the nurse managers' perception about decision support systems (DSS) as a moderator affect the relationship between tacit knowledge and strategic decision quality. Design: Descriptive correlational design. Setting: 12 hospitals affiliated to Assiut University. Subject: All nurse managers (N=255) working at Assiut University Hospitals. Study tools: Tacit knowledge scale, Decision support systems scale and Strategic decisions quality scale. Results: There was a positive correlation between decision support systems, tacit knowledge and strategic decision quality. Conclusion: Decision support systems play a moderator role in enhancing the relationship between tacit knowledge and strategic decision quality. Recommendations: Conducting training programs on nurses’ abilities to leverage DSS for strategic decision-making. Applying future studies at different health care settings to generalize the results.