Abstract: Organizational commitment refers to the extent to which an employee identifies with an organization and is committed to its goals. This study aim was to assess a set of variables that predict organizational commitment of nursing staff members, and to investigate the relationships among organizational commitment, organizational trust, and job satisfaction. This correlational cross-sectional was carried out on a convenience sample of 150 nurses in a Minia University Hospital. A self-administered questionnaire was used with an organizational commitment, an organizational trust, and a job satisfaction scales. Their reliability was good (Cronbach alpha coefficients 0.818, 0.728, and 0.831, respectively. Data collection was from April to May 2009. All the relevant principles of ethics in research were followed. The results revealed that 77.3% of the nurses had high commitment, while the organizational trust and job satisfaction were low, 48.0% and 24.0%, respectively. Job commitment had weak positive statistically significant correlations with trust (r=0.338), and job satisfaction (r=0.223). Job commitment and trust had weak positive statistically significant correlations with experience years, r=0.335, and r=0.210, respectively. On multivariate analysis, the statistically significant independent predictors of the nurses' commitment were their scores of job satisfaction and trust, and their marital status. The study concludes that despite the low levels of job satisfaction and trust, nurses' organizational commitment is high; still job satisfaction and trust are independent positive predictors of commitment. However, the study limitation of possible over-reporting of commitment and dissatisfaction needs to be considered interpreting the findings.