obacco control represents a key area in which nurses can make a significant positive impact on their patients’ lives. Despite this fact, however, nurses in certain countries are known to smoke tobacco at rates similar to or even exceeding those seen within the general population. The aim of the present study was to: 1) Identify factors that contribute for smoking among Saudi nurses in selected hospitals. 2) Explore the effects of smoking in the nurses' health status & 3) Estimate the nurses' desire for quitting smoking. Method(s): Descriptive cross-sectional study using, a calculated sample of 200 Saudi nurses, were chosen by systematic random method from king Fahad hospital in Alkhobar (60 nurses); Maternity & Children Hospital in Makkah (100 nurses) & King Faisal Hospital in Taif (40). Tool of data collection: An interview questionnaire sheet, - Data on smoking profile, Questions about desired for smoking,, Question about previous smoking cessation trials & intention to quit smoking. Results: Results of the present study revealed that, Most of sample age range between 20-<30(64%) years old, single women represent the highest percentage smoker 48% then married women 38%, half of the sample have the reason of smoking represented in the friends & 58% reported that, the increased of desire of smoking with the friends, majority of the nurses (90%) are used to smoke more than 7 cigarettes per day, & majority of the Smoking Saudi Nurses have the desire for quitting (80%). Conclusions & Recommendations: The present study concluded that smoking prevalence was relatively high among our hospital workers. The study was the first to explore smoking-related attitudes and behavior among the hospital nurses in Saudi Arabia. The findings indicate a critical need for raising healthcare Providers’ preparedness for implementing smoking cessation interventions in hospital settings and there is a need for higher quality evidence to determine with confidence all the health effects of tobacco smoking.