Abstract Background: Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease interferes with basic function of breathing of elderly. Aim: To evaluate the impact of implementing nursing protocol on respiratory function of elderly patients' with COPD. Subjects & methods: Quasi - experimental research design was utilized to conduct this study in Chest Diseases Departments at the Main Assuit University Hospital. A purposive sample of 169 elderly patients with COPD (87 study& 82 control groups) was participated. Three tools were used includes: 1st tool: Elderly patients assessment sheet, it includes 2 parts (Socio-demographic& health history and Bristol COPD knowledge sheet). 2nd tool observational check lists: used to assess the practice of elderly includes (breathing & coughing exercise, inhaler technique and incentive spirometer).The 3rd tool respiratory function …