قسم البحث
مجلة البحث
Medicinal Chemistry Research
الناشر
Springer International Publishing AG
تصنيف البحث
1
عدد البحث
Vol 21, No. 12
موقع البحث
NULL
سنة البحث
2012
المشارك في البحث
ملخص البحث
Several new 4(3H)-1,2,3-benzotriazinone derivatives were synthesized and tested for their anti-inflammatory activity and ulcerogenic effect. A docking study on the COX-2 binding pocket has been carried out for the target compounds to rationalize the possible selectivity. Among the tested compounds, the benzotriazinones linked to either thiadiazole (8) or oxadiazole (9) evoked the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site.