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A New Enniatin Antibiotic from the Endophyte Fusarium tricinctum Corda

مؤلف البحث
Ahmed M. Zaher, Makboul A. Makboul, Ahmad M. Moharram, Babu L. Tekwani, Angela I. Calderón
قسم البحث
مجلة البحث
The Journal of Antibiotics, Doi: 10.1038/ja.2014.129
الناشر
NULL
تصنيف البحث
1
عدد البحث
Vol. 68
موقع البحث
NULL
سنة البحث
2015
المشارك في البحث
ملخص البحث

Enniatins (ENs), a group of antibiotics commonly produced by various strains of Fusarium, are six-membered cyclic depsipeptides formed by the union of three molecules of D-α-hydroxyisovaleric acid and three N-methyl-L-amino acids. The endophyte Fusarium tricinctum Corda was isolated from the fruits of Hordeum sativum Jess. and cultivated on a rice medium. The fungal metabolites were extracted with methanol and were identified, employing liquid chromatography-mass spectrometry as ENs A, A1, B, B1, B2 and Q. EN Q is a new analog of EN A and the occurrence of EN B2 is reported for the first time from this endophyte, in addition to four well-known ENs (A, A1, B and B1). The methanol extract of F. tricinctum showed mild antibacterial and antileishmanial activities. Additionally the tested extract displayed inhibition of the activity of thioredoxin reductase enzyme of Plasmodium falciparum.