3-N-(4`-Hydroxy-3`-substituted phenyl)carbamoyl-1-methylpyridinium iodides (compds. 5b-j) and 3-carbamoyl-1-(N-(4`-hydroxy- 3`-substituted phenyl)carbamoyl) methyl pyridinium chlorides (compds. 7a-j) were synthesised and some of them were tested for their analgesic and antiinflammatory activities by hot plate test and carageenin-induced hind paw edema model, respectively. Compound 5b revealed the most potent analgesic and anti-inflammatory activities in comparison to sulfasalazine (SASP) and 5-ASA. In addition, ulcerogenicity, LD50, in-vivo and in vitro cleavage and pH stability of compound 5b were also determined.
تاريخ البحث
قسم البحث
مجلة البحث
Bulletin of Pharmaceutical Sciences Assiut University
عدد البحث
28 (2)
موقع البحث
https://bpsa.journals.ekb.eg/article_65398.html
سنة البحث
2005
المشارك في البحث
صفحات البحث
237-253
ملخص البحث