Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
11 Tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT), A Versatile Carrier System for Targeting Cell Cycle Checkpoint Pathways with Potential Anticancer Activities 2024
12 Spectral, XRD, morphological, DFT, and molecular modeling investigations of newly prepared isatin Schiff base complexes 2024
13 Carbon Nano-Dots based potentiometric sensor for the assay of the antiviral agent; Valacyclovir: In-Depth DFT Calculations, application to the pharmaceutical formulation and greenness assessment 2024
14 Design, synthesis, and molecular docking of novel 1,3, 4-triaryl pyrazole derivatives bearing methylsulfonyl moiety with anticancer activity through dual targeting CDK2 and COX-2 enzymes 2024
15 Thiadiazine-2-thione Derivatives as New Carrier Systems for Isothiocyanates and Dithiocarbamic acid with Potential Anticancer Activities 2023
16 Thiadiazine-2-thione derivatives as new cell- cycle inhibitors 2023
17 New Cell Cycle Checkpoint Pathways Regulators with 2-Oxo-indoline Scaffold as Potential Anticancer Agents: Design, Synthesis, Biological Activities and In Silico Studies 2022
18 Novel Azine Linked Hybrids of 2-indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies 2022
19 New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia 2022
20 Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives 2022