Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
11 Design, synthesis, and molecular docking of novel 1,3, 4-triaryl pyrazole derivatives bearing methylsulfonyl moiety with anticancer activity through dual targeting CDK2 and COX-2 enzymes 2024
12 Quinazoline‐chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in‐silico studies of potential anticancer activity against multiple myeloma 2024
13 Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies 2024
14 An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a] pyrimidines 2024
15 Thiadiazine-2-thione derivatives as new cell- cycle inhibitors 2023
16 Thiadiazine-2-thione Derivatives as New Carrier Systems for Isothiocyanates and Dithiocarbamic acid with Potential Anticancer Activities 2023
17 Novel Spiro Hybrids of 2-indolinone and Thiazolodinone Scaffolds as Cell Cycle Checkpoints’ Pathways Regulators with potential anticancer activity 2022
18 Structure Based Design of Novel Azine Linked Hybrids of 2-Indolinone- Thiazolodine Scaffold as Potential Quorum Sensing Inhibitors for Fighting Antimicrobial Resistance 2022
19 In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations 2022
20 Phytochemical investigation, molecular docking studies and DFT calculations on the antidiabetic and cytotoxic activities of Gmelina philippensis CHAM. 2022