Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation.

Faculty of Pharmacy

Assiut University

Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation.

Research Authors
Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu.
Research Department
Department of Pharmacognosy
Research Journal
Synthetic and Systems Biotechnology
Research Publisher
Sciencedirect
Research Rank
1
Research Vol
1
Research Website
http://www.sciencedirect.com/science/article/pii/S2405805X15300223
Research Year
2016
Research Member
Wael Mostafa Abdel-Mageed Mostafa
Research Abstract

Abstract
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.