Skip to main content

Solid dispersion technology, a contemporary overview on a well established technique

Research Authors
Mahmoud A. Younis
Research Department
Research Journal
Universal Journal of Pharmaceutical Research
Research Publisher
NULL
Research Rank
1
Research Vol
(3)2
Research Website
http://www.ujpr.org/wp-content/themes/asb-ujpr/images/review/UJPR-2-3-RW1.pdf
Research Year
2017
Research Abstract

Solubility is a significant physicochemical parameter that affects the absorption, bioavailability and therapeutic effectiveness of any drug. Formulation development would fail if drug has a poor aqueous solubility. The low aqueous solubility of drug substances will lead to inadequate absorption and consequently, low bioavailability. Improvement of the aqueous solubility and dissolution rate of hydrophobic drugs remains one of the most difficult challenges in drug development process. Among various techniques used to improve poor aqueous solubility of drugs, solid dispersion technology has been extensively used in the literature and has become one of the well-established pharmaceutical procedures during formulation process. Although the technique seems to be “a part of the past”, literature tells us that it is still used and developed to suit current needs of pharmaceutical industry. This review article highlights recent advances in solid dispersion technology and its applications in contemporary pharmaceutical research.