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The role of cluster of differentiation 39 (CD39) and purinergic signaling pathway in viral infections

Research Abstract

CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect. CD39 regulates the function of a variety of immunologic cells through the purinergic signaling pathways. CD39+Tcells have been implicated in viral infections, including Human Immunodeficiency Virus (HIV), Cytomegalovirus (CMV), viral hepatitis, and Corona Virus Disease 2019 (COVID-19) infec tions. The expression of CD39 is an indicator of lymphocyte exhaustion, which develops during chronicity. During RNA viral infections, the CD39 marker can profile the populations of CD4+ T lymphocytes into two populations, T-effector lymphocytes, and T-regulatory lymphocytes, where CD39 is predominantly expressed on the T-regulatory cells. The level of CD39 in T lymphocytes can predict the disease progression, antiviral immune responses, and the response to antiviral drugs. Besides, the percentage of CD39 and CD73 in B lymphocytes and monocytes can affect the status of viral infections. In this review, we investigate the impact of CD39 and CD39-expressing cells on viral infections and how the frequency and percentage of CD39+ immunologic cells determine disease prognosis.

Research Authors
Alaa Elsaghir, Ehsan MW El-Sabaa, Abdulrahman K Ahmed, Sayed F Abdelwahab, Ibrahim M Sayed, Mohamed A El-Mokhtar
Research Date
Research File
Research Journal
Pathogens
Research Pages
279
Research Publisher
MDPI
Research Rank
Q2
Research Vol
12
Research Website
https://www.mdpi.com/2123356
Research Year
2023

Results of Appeals for Pharm D Students – Applied and Forensic Pharmacognosy (Practical and Practical-Theoretical Exams)

After reviewing the appeals submitted by students for the Applied and Forensic Pharmacognosy course regarding the practical and practical-theoretical examinations, and after rechecking the correction of the exam papers to ensure the accuracy of the marked questions and the total score calculation,

it was found that no student is entitled to any additional marks.

news category
إعلانات الطلاب

Congratulations

Professor Dr. Gihan Nabil Hassan Fetih
Dean of the Faculty

Together with the Vice Deans, Heads of Departments,
Professor Dr. Director of the Quality Assurance Unit,
and the Faculty Secretary,

extend their sincere congratulations to the faculty family on the occasion of:

Renewal of the International Standard Certification
ISO 9001:2015

and the awarding of the International Standard Certification
ISO 21001:2018

for the Educational Organizations Management System,
for the first time.

Congratulations to all.

news category
خبر عام

Discussion of the Thesis Submitted by Pharmacist / Shaimaa Abdel-Sayed Yassin – Registered for the Master’s Degree in Pharmaceutical Sciences (Pharmaceutical Organic Chemistry) from Abroad on Thursday, January 15, 2026

Renewal of ISO 9001:2015 Certification and Granting of ISO 21001:2018 Certification to the Faculty of Pharmacy for the First Time

Under the patronage of
Prof. Dr. Ahmed Al-Manshawy, President of Assiut University,
and Prof. Dr. Jihan Nabil Fetih, Dean of the Faculty of Pharmacy,

The Faculty of Pharmacy received the delegation of AJA – Egypt on Monday, January 12, 2026, to conduct the annual surveillance audit for the renewal of the ISO 9001:2015 certification related to the Quality Management System. The visit also included the evaluation of the Faculty’s compliance with the requirements of the ISO 21001:2018 international standard for Educational Organizations Management Systems, for which the Faculty applied for the first time. This standard represents an effective tool enabling educational institutions to demonstrate their commitment to effective educational management practices.

This comes within the framework of the Faculty’s efforts to achieve the Fourth Sustainable Development Goal, which the Faculty adopts to ensure inclusive, equitable, and quality education, and to promote lifelong learning opportunities for all.

The visit included an opening meeting with the audit team, attended by:

  • Prof. Dr. Jihan Nabil Fetih, Dean of the Faculty
  • Prof. Dr. Hassan Refaat, Vice Dean for Education and Student Affairs
  • Prof. Dr. Noha Nahid Attia, Vice Dean for Community Service and Environmental Development
  • Prof. Dr. Jilan Abdel-Razek Abdel-Aleem, Director of the Quality Assurance Unit
  • Dr. Marwa Ahmed Sayed, Deputy Director of the Quality Assurance Unit
  • Prof. Dr. Yasser Ghallab, Head of the Pharmacognosy Department and Coordinator of the Clinical Pharmacy Program
  • Mr. Tarek Sayed, Faculty Secretary

Following this, the audit team conducted inspection visits to the Faculty’s various departments, administrative units, facilities, and buildings. Meetings were also held with different stakeholders to review documents and examine the applied procedures.

The visit concluded with a closing meeting during which feedback was presented. The audit team recommended the continuation of the ISO 9001:2015 certification and the granting of the ISO 21001:2018 certification to the Faculty of Pharmacy for the first time.

 

news category
خبر عام

Selective detection of terminal alkyne acaricide via click-reactive carbon dots: applications in food safety monitoring

Research Authors
Ramadan Ali, Khalid Alhazzani, Ahmed Z Alanazi, James Barker, Aya M Mostafa, Mohamed M El-Wekil, Mohamed N Goda, Al-Montaser Bellah H Ali
Research Date
Research Journal
Analytical Methods
Research Pages
8923-8934
Research Publisher
Royal Society of Chemistry
Research Website
https://pubs.rsc.org/en/content/articlelanding/2025/ay/d5ay01524c/unauth
Research Year
2025
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