Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
The practical exam for the elective course
"Computer-Aided Drug Design" for 5th-Year Pharm D students will be held in the computer labs
for Group (A) and Group (B) as follows:
|
Day |
Date |
Group |
Time |
|
Monday |
28/04/2025 |
Group (A) |
12:00 PM |
|
Tuesday |
29/04/2025 |
Group (B) |
12:00 PM |
All students must attend according to their assigned group and time.
No makeup exam will be given without an officially approved excuse.
The department announces that the second mid-term exam and the practical theory exam will be held on Saturday, April 26th, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Venue: Hall 2, beneath Lecture Hall B
Course Content for the mid-term Exam (10 Marks):
Course Content for the Practical Theory Exam (15 Marks):
The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Exam Venues:
The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.
Please make sure to attend on time, as the exam will not be repeated.
Exam Venues:
The Practical Exam for First-Year Students in the course Pharmacognosy (1) will be held on:
? Monday, April 28th, 2025
? Time: From 8:30 AM to 10:00 AM
? Location: Department Laboratories
Students will be distributed as follows:
|
Lab |
Floor |
Student Numbers |
Examples of Names |
|
Lab (A) |
4th Floor |
From 2241002 to 2241038 |
Abanoub Nasser Ibrahim – Joey Mokhtar Roshdy |
|
Lab (B) |
4th Floor |
From 2241040 to 2241070 |
Habiba Sayed Ahmed – Sohaila Khaled Ali Mohamed |
|
Lab (C) |
4th Floor |
From 2241073 to 2241111 |
Shahenaz Mohamed Ahmed Othman – Mohamed Yassin Mohamed |
|
Lab (D) |
4th Floor |
From 2241112 to 2241146 |
Mahmoud Abdelrahman Abdelrahman Mohamed Abdelkader |
|
Lab (B) |
3rd Floor |
From 2231005 to 2231110 |
Ahmed Fawzy Abdel-Aal – Mohamed Gamal Mohamed |
? Note:
It has been decided to hold the practical exam for National University students (course Pharmacognosy -2) on Tuesday, April 22, 2025, at 10:00 AM in Lab (D), 4th floor.
Phytotherapy Course – Theoretical and Practical Exam
For Clinical Pharmacy Students – Class (10)
The theoretical and practical exam for the Phytotherapy course will be held as follows:
? Date: Sunday, April 27, 2025
? Time: To be announced later
? Venue: Hall (2), beneath the lecture Halls
Finding effective and selective anticancer agents is a top medical priority due to high clinical treatment demand. However, current anticancer agents have serious side effects and resistance development remains a big concern. This creates an urgent need for new multitarget drugs that could solve these problems. Tetrahydrocarbazoles and 5-arylidene-4-thiazolinones have always attracted researchers for their multifaced anticancer activities and the possibility to be easily derivatized. Thereby, herein we report the combination of the two scaffolds to provide compounds 9a-j and 10a-j that were fully characterized and their tautomeric form was confirmed by crystal structure. 9a-j and 10a-j were assessed for in vitro antiproliferative activity using SRB assay against a panel of seven human cancer cell lines with doxorubicin as the standard. The results revealed that the cell lines derived from leukemia (Jurkat) and lymphoma (U937) are the most sensitive. Compounds 9d, 10e, 10g, and 10f revealed the highest potency (IC 50 (IC 50 = 3.11–11.89 μ M) with much lower effects on normal lymphocytes cell line >50µM). The results show that modifications at 6th position of the THC and the nature of the substituent at the arylidene moiety affect the activity. To exploit the mode of action, 9d, 10e, 10f, and 10g were evaluated as VEGFR-2 and EGFR inhibitors. 10e is the most potent (IC 50 0.26 and 0.14 μ M) against both enzymes. It also induced G0-G1-phase cell cycle arrest and apoptosis. While 10g exhibited higher potency (IC 50 vincristine (IC 50 15.63 μ 9.95 μ M) than M) against tubulin. A molecular docking study was carried out to understand the in teractions between 10e, 10g and their targets. This study reveals 10e and 10g as possible candidates for developing multitarget anticancer agents against leukemia and lymphoma
